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Table 1 Correlation of demographic, clinico-pathological parameters of breast cancer patients with mean percentage of CD3+, CD8+ and CD45RO+ T lymphocytes

From: CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

   CD8+   CD3+   CD45RO+  
Parameters No (%) Mean (SD) p Mean (SD) p Mean (SD) p
Age    0.27   0.30   0.37
 < 50 18 (47.4 %) 15.1 (10.2)   39.1 (23.6)   34.6 (30.9)  
 50+ 20 (52.6 %) 19.7 (12.2)   48.0 (26.7)   42.6 (22.6)  
Gender
 Female 43 (100.0 %) 16.7 (11.3)   43.2 (25.3)   38.2 (26.1)  
Diagnosis    0.09   0.35   0.24
 IDC 38 (88.4 %) 18.1 (11.1)   44.1 (25.3)   36.5 (26.8)  
 ILC 3 (7.0 %) 4.5 (2.3)   50.0 (26.2)   62.7 (3.1)  
 Others 2 (4.7 %) 10.5 (13.4)   18.5 (19.1)   33.0 (7.1)  
Grade    0.48   0.14   0.44
 1 5 (11.6 %) 11.0 (6.9)   33.2 (25.2)   38.4 (19.0)  
 2 23 (53.5 %) 18.0 (9.9)   50.4 (26.2)   42.5 (25.2)  
 3 15 (34.9 %) 16.9 (14.0)   34.9 (21.3)   31.0 (29.6)  
LVI    0.39   0.12   0.21
 Positive 18 (41.9 %) 14.9 (11.5)   36.1 (25.8)   32.3 (28.6)  
 Negative 25 (58.1 %) 18.0 (11.2)   48.5 (24.0)   42.6 (23.8)  
Lymph node    0.29   0.04   0.32
 Positive 19 (63.3 %) 17.7 (10.1)   47.9 (28.2)   41.5 (28.1)  
 Negative 11 (36.7 %) 13.3 (11.1)   30.6 (13.8)   30.7 (27.1)  
Estrogen receptor    0.086   0.87   0.74
 Positive 25 (58.1 %) 13.8 (7.3)   42.7 (26.4)   37.0 (22.4)  
 Negative 18 (41.9 %) 20.7 (14.5)   44.0 (24.4)   39.9 (31.4)  
Progesterone receptor    0.086   0.87   0.74
 Positive 25 (58.1 %) 13.8 (7.3)   42.7 (26.4)   37.0 (22.4)  
 Negative 18 (41.9 %) 20.7 (14.5)   44.0 (24.4)   39.9 (31.4)  
HER2/neu    0.006   0.83   0.56
 Positive 11 (25.6 %) 24.5 (13.5)   44.7 (25.0)   33.9 (26.3)  
 Negative 32 (74.4 %) 13.8 (9.0)   42.7 (25.8)   39.5 (26.3)  
Molecular subtype    0.034   0.48   0.82
 Luminal Aa 23 (53.5 %) 13.5 (7.4)   44.7 (26.7)   37.3 (23.3)  
 Luminal Bb 2 (4.7 %) 17.0 (8.5)   21.5 (9.2)   34.0 (5.7)  
 TNBCc 9 (20.9 %) 14.5 (13.0)   38.2 (24.3)   45.3 (33.6)  
 HER2/neu Positived 9 (20.9 %) 26.1 (14.2)   50.5 (24.5)   33.9 (29.8)  
  1. IDC Invasive ductal carcinoma, ILC Invasive lobular carcinoma, SD standard deviation, LVI Lymphovascular invasion
  2. aLuminal A = ER (+ve) and/or PR (+ve) and HER2/neu (−ve); bLuminal B = ER (+ve) and/or PR (+ve) and HER2/neu (+ve); cTNBC: Triple negative = ER (−ve) and/or PR (−ve) and HER2/neu (−ve); dHER2/neu positive = ER (−ve) and/or PR (−ve) and HER2/neu (+ve)